How SAM-E works - What Is SAM-E?
SAM-E Role In The Production Of Neurotransmitters
Levels of SAM-E have also been shown to influence the body's production of melatonin, serotonin, and dopamine. These important neurotransmitters and hormones control sleep, mood and social interaction. All of which are effected by depression.
When glutathione is depleted, the liver simply can't do its job. The liver has special SAM-E enzymes just for regenerating tissue through glutathione production.
Glutathione is also found in other organs. One of glutathione's most important functions is to act as a potent free radical scavenger in the eye, where it protects against cataracts caused by UV sunlight. By providing the building blocks of glutathione, SAM-E contributes to maintenance of this important natural antioxidant.
Many of the chemicals used to induce cancer in lab animals work by inhibiting SAM-E. It is well documented that methyl deficiency produces liver cancer in rodents. Also, certain genes must be methylated in order to keep cancer from starting. After five weeks of a methyl-deficient diet, rats show cell changes.
In treating osteoarthritis, SAM-E protects both the synovial fluid and cartilage cells that are important to joint health. People suffering from osteoarthritis usually have damage to one or both of these important "joint cushions". Researchers theorize that SAM-E, like NAC, protects synovial cells by reversing glutathione depletion. It may also protect synovial cells by blocking the enzymes that degrade cartilage. In the test tube, SAM-E increases the number of chondrocytes (cartilage cells) and proteoglycans (protein). This suggests that SAM-E treatment may reverse the underlying process of osteoarthritis by stimulating cartilage to grow.
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